Parvo testing in Pregnancy

Submitted by amh10 on 13 December, 2006 - 15:10
  • Recent parvovirus B19 infection can be confirmed or excluded by testing for parvovirus B19 specific IgM on the first serum obtained.
  • Failure to detect parvovirus B19 specific IgM excludes infection in the four weeks prior to collection of the serum. Hence infection cannot be excluded if investigation commences more than four weeks after onset of rash illness (vide supra, rubella).
  • If parvovirus B19 IgM is detected in the first 20 weeks of pregnancy, confirmation is required by alternative assay, eg M-capture RIA, IgM specific immunofluorescence or IgG seroconversion using an antenatal booking blood. Repeat testing will demonstrate a decline in IgM reactivity and provide an additional confirmation method.

AMH

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